Thursday, March 1, 2012

892. The FLUTD cat died - why?

March 1, 2012
892. The FLUTD cat died - why?
March 1, 2012

Today I had a meeting with the young couple from 9.40 am to 11.30 am as the young couple wanted answers as to why their 8-year old neutered male cat had died during treatment at Vet 2 which was associated with a veterinary surgery of Vet 1.

The cat had an inflamed penis and difficulty in peeing and in the opinion of the owners, should not have died based on this medical condition. It was a reasonable deduction and the husband had emailed me informing me of the cat's death as I had treated him in April and November 2011for Feline Lower Urinary Tract Disease (FLUTD). This case is reported in
http://www.sinpets.com/F5/20110437urinary-tract-infection-amitriptyline-cystitis-toapayohvets-singapore.htm

Basically, XXX had a relapse of FLUTD and the couple had sent him to Vet 1 for treatment, owing to proximity of location.

Answers were wanted as Vet 2 had performed an autopsy and said that the cause of death was unknown.

"Could it be anaphylaxis or allergy to cefloxalin given together with the calcium in the IV drip?" the wife wanted to know as she had researched the internet and there was information on the adverse drug reactions using the combination, in human beings.
"It is very difficult to ascertain that the drugs had caused his death," I said as the owner had described that the cat was discharged home in a stoned state, being unable to stand or walk normally and then had pale gums and breathing difficulty in the evening. The cat was rushed to Vet 2 around midnight and he passed away despite X-rays and treatment. "Adverse drug reactions in people may not apply to the cat and vice versa."

So, what was the cause of death? The couple had spoken to the proprietor of the surgery but was no wiser. They showed me the medical records and 2 X-rays taken before death. One lateral X-ray showed black air inside the lung. The V/D X-ray showed that the lungs and chest area were opaque. It was hard to explain why.
The blood test showed a low platelet count.

Low platelet count. I discussed the case later with Dr Daniel who said that the cat have died of internal bleeding leading to or as a result of low platelet count. It was plausible. For example, traumatic injury to the lung (lung bleeding was reported in the autopsy) due to the "feisty" cat being nursed and changing of the litter, catheter and urination bag etc.

But the low platelet count by itself would not have killed this cat as I have had seen such cases of lower platelet count in toxaemia and tick fever and the dogs survived.

"In any case, an autopsy done by the same practice would not be credible as there was a conflict of interest," I said. "An independent veterinary body ought to have done the autopsy." The owner was not aware of the need for this procedure.

Vitamin C dosage The cat was given high doses of Vitamin C daily by IV during the 5-day hospitalisation. "This practice believes in high doses of Vitamin C in treatment," I said. "Whether the dosage killed this cat, it is hard to determine."

Sedation - valium and ketamine IV during hospitalisation. Would the daily IV injection to sedate the cat for ease of handling and changing of the litter cause death by cumulative dosage in an old cat that was already stressed out and frightened? I believe it would but Dr Daniel disagreed. This would account for the owner's observation that the cat could not lift up his head, that his eyes could not track finger movement and that after the 2nd day of hospitalisation, the cat looked "stoned" and could not even give a soft meow as usual.

"Why would the vet discharge a cat when he was not well?" the wife asked me.
"It could be that the cat would be better nursed at home," I said. "Since the cat was feisty (aggressive), it would be very difficult for the nurses to nurse and clean him. In the first place, this cat could have been better nursed at home. Vet 1 had proposed home nursing with the catheter inside the bladder. Struvites were reported and this would be much better to manage at home for a ferocious cat.

I can't figure out why the owner did not consult me after Vet 1's treatment was unsatisfactory in their opinion. This was what they did in April 2011 and then in November 2011. Proximity to Vet 1 was the reason given for this time-pressed couples.

"I would not go to the same car mechanic near my house if I know that he had not repaired my car to my satisfaction," I said frankly to the couple as they were the type who wanted answers to a death of the cat for knowledge and prevention and not for litigation. We could converse frankly rather than beat around the bush. "For car in bad state, it would be for safety reasons. For a pet, it could be a matter of life and death."

It was difficult to find the correct answers to this cause of death. I believe it was the cumulative effects of sedation. I could imagine that another dose of sedation was given (as stated in the records) every day as the cat showed ferocity when the litter was changed daily or frequently. There was the urinary bag attached to the catheter to be changed. Medical records stated the cat was "feisty" on two days and so sedation had to be given.

"What should we do if we have a cat?" the wife asked.

"Get a female cat," I said. "FLUTD is less likely in a female cat. For male cats or dogs with struvite urinary stones, a monthly urine test and 3-monthly X-rays for pets with struvite urinary stones is advised. But no cat owner will comply."

"Did you follow my instructions that the cat should not be given treats?" I asked. "I had recorded 'no treat' in the blood test result too." See:
http://www.kongyuensing.com/pic/20110555male-neutered-cat-house-shifting-FLUTD-urine-test-toapayohvets-singapore.jpg

The cat was given canned C/D diet after 2 months of S/D diet since April 2011 when the couple had consulted me.

"Well, 2 weeks before consulting Vet 1 in February (2012), I did give him dental treats."

"This should not be given," I said. "Struvites could be formed as a result and this lead to urination difficulty and an inflamed penis."

"The penis was inflamed because the tip of the penis had been bitten off," the wife said. "You were the one who told us in April 2011. Do you remember? You extracted the broken canine tooth as that could be the cause of irritation and injury. So his penis was diagnosed 'inflamed' by Vet 1 but it was due to the fact that he had no tip."

Owners who love their pets very well remember all treatments like elephants as their pets are family. "I remember Tobi for his hissing at me," I said. "He did not like vets. Did you give other treats as well?"

"Some love letters, as it was Chinese New Year," the wife recalled.

"Some, but not all cats and dogs with a history of struvites in their urine cannot eat other food as the problem will come back to cause peeing difficulty," I said. Her cat was one of this category. If the owner gives a strictly controlled diet, usually there is no problem.

It was a sad day and I hope that the couple had received some answers as everyone learns from experience. There is no other way. Reading widely on your pet's health problems may give insights and knowledge of what had happened to other people's pet and thereby instituting preventive measures to ensure that your pet's health is optimal. For example, dental scaling to keep the teeth and mouth free from infection, enabling the cat to eat well and without pain. Cats need to groom themselves and therefore clean teeth without periodontal diseases are more important to them as compared to the dog.

Proximity to the vet surgery is convenient but sometimes, it is best to find a vet that can handle your pet's more complex health problems. A practice that has different doctors attending to your pet may not be in the interest of your pet. However the same vet treating your pet may not be suitable and a second opinion may be needed if the outcome of treatment is not to your satisfaction.

something wrong with uploading by blogger.com in previous post - megaesophagus

I upload again

890. esophageal diverticula seen on barium meal x-ray & megaesophgus

"Barium meal X-ray may be risky," the newly graduate vet told me. "The dog may inhale it and cause aspiration pneumonia. The megaesophagus can be seen in the plain x-ray."

"Megaesophagus may be obvious to vets," I said. "But my owner is not able o visualise it in the plain X-ray. Give the dog the barium meal." The dog had been coughing frequently in the past week and for the past 3 months he was regurgitating white mucus daily and coughing too.




Proof is in the barium meal X-ray. Esophageal diverticula is an incidental finding. The white mucus could be accumulated there. Gland secretion of the esophagus? Irritation and inflammation of this cranial part of the esophagus cause coughing. Real coughing, not just attempts at retching. The sounds were similar to "kennel cough" - see my video on kennel cough in a dog.

Wednesday, February 29, 2012

Sunday's interesting cases - ringworm or not ringworm in a Sheltie

Sunday 26, 2012. Bright sunshine. Went to NATAS fair at Changi expo at 9.30 am to see what was available in the travel industry and new ideas on marketing. My assistant phoned to say I had an appointment at 11 am.

"Sheltie very itchy below the penis," said the gentleman. I thought it was penile trauma or inflammation of the prepuce. On seeing the dog with Dr Daniel, I saw the red circular spots and the crusted centre. "Ringworm," I said. "Had the dog been to the groomer recently?"

"2 weeks ago," the owner said.
I showed the ringworm hairs to Dr Daniel. He was not convinced saying that those could be damaged hairs, due to the dog licking the ventral area, causing inflammation and rashes.

He didn't buy into my microscopic exam of ringworm hair. Each vet has his own ideas but there are certain presentation that cannot be ignored.

"Circular rings, reddish with crusty scales in the centre," i said. These are typical presentation.

"Needs confirmation with fungal culture," he said. This is what the professors teach.
"Yes," I said. "But the owner cannot wait 2 weeks for the culture to prove it is ringworm. He wants prompt action and successful outcome."

In fact the couple had a bare patch on the dog's left shoulder area diagnosed "ringworm" by Vet 1 from Toa Payoh Vets. Since it did not resolve and the dog was still scratching, he went to Vet 2 who diagnosed demodectic mange.

"How many mites he showed you?" I asked the gentleman banker.
"One mite," he described the cigar shape.
"Well, it is possible that it is demodectic mange on that hot spot," I said. "In any case, demodectic mites are normally present in dogs, as are bacteria in our mouth. Ringworm takes more than 1 week to cure."

I did not want to defend Vet 1's "misdiagnosis" as the gentleman would not believe me. Vet 2 had cured his dog and that was results. "Yellow pimples," he said.

888. Megaesophagus in the older dog - treatment

Regurgitation is the presenting sign. Mistaken for "vomiting" which is a projectile action.

D/D for regurgitation
1. Esophageal obstruction. Vascular ring anomaly, stricture, foreign body, neoplasia (spirocerca lupi).
2. Motility disorders. Megaoesophagus - congential
- acquired --- primary (idiopathic)
--- secondary
Dysautonomia
3. Inflammatory. Esophagitis (secondary to protracted vomiting), caustic irriation. Hiatal hernia. Gastro-esophageal reflux.
4. Others. Diverticula, Broncho-esophageal fistula.
5. Idiopathic.


DIAGNOSIS
1. History - Other clinical signs, young or older breed, large breed
2. Physical exam - incl full neurological exam, thorough thoracic auscultation (aspsiration pneumonia, caudal lobes on X-ray)>

THORACIC X-RAY. Needs 3 views. 2 lateral + V/D. Look for aspiration pneumonia, cranial mediastinal mass, air in esophagus (one lateral without sedation as drugs can cause air in esophagus).

Contrast studies. Liquid barium using plain X-rays, evidence of strictures, vascular ring anomaly (puppies).

Food and barium dynamic studies (fluoroscopy) to assess motility of esophagus.

Other investigations to identify underlying problems.

TREATMENT depends on causes

Distemper, autonomic drugs, toxicity (lead, thallium, anti-cholilnesterase), esophigitis, systemic lupus erythematosus, hypoadrenocorticisum, thyoma, myasthenia gravis (focal, most common cause, auto-antibodies produced againt Ach receptors), polymyositis.

1. Vertical feeding - Feed from a height. Bailey's chair. 1 hour upright feeding.
2. Bethanechol or cisapride for myasthenia gravis

CASE STUDY
Use of barium meal showed esophagus enlarged in two areas, convincing the owner of the diagnosis. Plain X-ray not so clear in showing megaesophagus.
2. Dietary - canned food, meat balls. No dry food.
3. If myasthenia gravis, require anit-cholinesterase drugs and immune suppression.
bethanechol or cisapride

Tuesday, February 28, 2012

Follow up on guinea pig that suddenly passed blood in urine

Guinea pig, male, young, had passed blood in the urine some weeks ago. Vet 1 diagnosed UTI. Recovered after some days.

Again blood in urine. Sent to Toa Payoh Vets. Consulted me with Dr Daniel. Another recurrence of UTI? "The blood looks clean and bright red," I said. "It is unlikely to be UTI. Collect some urine for urine analysis."

How to collect urine? This is not a male dog or cat. A small male guinea pig that is much loved by his mistress who had consented to more detailed investigations rather than the usual injection and go home to wait and see. "Practise evidence-based medicine," I always advise my vets. "Feeling that it is not UTI or it is UTI is not sufficient. Feeling is not not enough". So, I had to practise what I preach and collect the urine from this little one.

Well, one must improvise as the urine must be clean and not be contaminated from faecal stools. Pictures showed.






After one day of treatment and rest, the guinea pig went home. I phoned the owner yesterday, Feb 27, 2012, around 7 days later. No more problem since going home.


FOLLOW UP ON A LITTLE GUINEA PIG'S HEALTH

Her reply on Feb 27, 2012 is as follows:

Hi Dr Sing,

The only time he's elevated to a height is when I carry him to bathe once a week. However, I have never dropped him before. He doesn't struggle at all. No one else carries him, they usually pat him when he's walking around on the floor (with supervision). When I carry him, I am seated on e floor too.

His whole cage is cleaned and wiped down with diluted vinegar or pet surface sanitizer (by byopet) at least twice a day
(morning and evening) or more.

After he got back from your clinic, he's been eating well n drinking well, a lot of hay and pellets. I feed him small portions of vegetables twice a day (either lettuce, baby carrots or cucumbers).

Thank you.

Sent from my iPhone

886. Closed pyometra email


E-MAIL TO DR SING DATED FEB 28, 2012



Hi Dr Sing


I would appreciate your advice on my dog's case.


My dog is an unspayed female Shih Tzu whose age is estimated to be around 5-6yr old(no exact age as we adopted her when she was found abandoned and in bad condition). Her weight is 3.95kg.

Her last heat ended around 30th November 2011.
She is suffering from bad case of skin problem and is drinking more water and has slimmed down. Her appetite is good with no vomiting and diarrhoea. No discharge or blood in urine observed.


I sent my dog to the vet for her skin problem and the blood test results showed elevated WBC (26.92+). As she is observed to be drinking more water coupled with elevated WBC and her unspayed status, the vet suspected it might be closed pyometra.

No X-ray or ultrasound was done due to financial concerns. Skin scrape was negative for demodex. According to the vet, blood work showed no other abnormalities. However, her T4 readings is quite low (1.3) on the normal range (1.1-4.0 UG/DL).
I can email you the blood work results once I get them scanned should you require them.

Vet prescribed Baytril 50mg tablet(1/2 tablet daily) and to recheck in 2 weeks time. She is also too skinny and vet gave Troy Nutripet gel to supplement her diet.


I am very concerned about the dangers of pyometra and would like to seek your advice. As her body is already stressed by her skin condition and her malnourished state, I am very lost.
I do not know if putting her on the antibiotics and supplementing her health in preparation for the surgery while observing for sudden changes before the next consult would be advisable? Or should I just opt for early surgery since her bloodwork suggests generally healthy organ functions.
Do you think it is possible for her to be operated by you without performing the imaging tests? What is your estimated total charges for the surgery? Please kindly advise. Thank you very much.


Best Regards
Name given




E-MAIL REPLY FROM DR SING DATED FEB 28, 2012


E-MAIL REPLY FROM DR SING DATED FEB 28, 2012

I am Dr Sing. Thank you for your email.
It is risky to diagnose closed pyometra by email without examination of the patient. I will give you my opinions based on your email report on the understanding that it is best to have an examination by me, if practical.


1. Closed pyometra occurs in a dog that has her heat period around 2-3 months ago and your dog was in this situation. She had increased white cell count and was drinking more. I presume she has weight loss over the last 2-3 months. Pl email your vet's reports and blood test results.

2. However, skin disease and poor health can also cause increased white cell count and thirst due to skin infections and itchiness. Drugs may also increase thirst or appetite if your vet had earlier treated the dog.

3. As your dog has good appetite and no vomiting, it is possible that, at the time of consultation, she does not have closed pyometra, assuming she had not been given any drug to treat her skin disease or other health problems.

QUESTIONS

3.1. Did your vet palpate the abdomen and let you know the results of his or her palpation as to whether he or she felt an enlarged uterus? Abdominal palpation is an alternative to X-rays and ultrasound and if the uterus is enlarged, it can be palpated by the vet. Closed pyometra can be confirmed just by palpation but imaging is sometimes necessary to "convince" the owner of the presence of the enlarged uterus.

3.2 Did your dog have fever at the time of consultation? What was the rectal temperature?

3.3 When did the weight loss start? Was it after November 30, 2011 or was the dog losing weight for many months?

4. In reply to your questions about spaying your dog without imaging, it is possible. My estimated charges for the operation would be around $250-$300 for a normal spay and around $500 - $600 for a pyometra spay as this takes a longer time and requires IV drip.

5. It is prudent to wait 2 weeks or longer for your dog to recover from the infection and put on weight, before any spay surgery is attempted. The skin disease should be cured first. The cause of the weight loss may be due to the start of closed pyometra if weight loss is recent.

Another blood test can be done to check the total white cell count prior to surgery, if possible.

6. Closed pyometra is sometimes difficult to diagnose when the uterus is not full of pus. Usually there is loss of appetite. Yet you said your dog has "good" appetite but is losing weight. Why? A typical Shih Tzu with good appetite at middle age should be weighing more than 3.95 kg, at around 5-6kg. Therefore, I don't think that your dog has "good appetite."

I hope the above answers your questions.