3298. Tick fever IN DOGS and IMIDOX

A Miniature Schnauzer tested postive for Anaplasma antibodies some 3 weeks ago. The dog was given 0.4 ml Imidox and started eating. So the owner did not come back for a second injection 2 weeks after the first. The dog vomited many times. Now the dog had jaundice and is now positive for Anaplasma and Babesia.

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Imidox^® is an injectable solution that cures redwater (Babesiosis) and tick-borne gallsickness (Anaplasmosis) in cattle.  It can be used in cattle for the prevention of Asiatic redwater for up to 4 weeks and African redwater for up to 8 weeks.  Imidox^® is also indicated for the treatment of equine and canine Babesiosis.

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Imidocarb dipropionate 120 mg, excipients .q.s.ad. 1 mL

Indications

For the treatment and prevention (before the introduction of livestock to areas of risk) against piroplasmosis, anaplasmosis (both also known as "tick fever"), ehrlichiosis, hepatozoonosis and cytauxzoonosis.

Dosage and Administration

Piroplasmosis: cattle, sheep and goats: 1 ml/100 kg; horses: 2 mL/100 kg; dogs and cats: 0.25 mL/10 kg. Anaplasmosis and piroanaplasmosis: cattle, sheep and goats: 2.5 mL/100 kg; Ehrlichiosis: dogs: 0.5 mL/10 kg of b.w.; Cytauxzoonosis: cats: 0.2 mL/10 kg of b.w. Apply through intramuscular route in horses, and preferably subcutaneously in the dorsal area of cattle, sheep, goats, dogs and cats.


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COMPOSITION:

Contains per ml:
Imidocarb dipropionate 120 mg

DESCRIPTION:

Imidocarb dipropionate is highly active against infections caused by adult and immature stages of Babesia in cattle, sheep, horses and dogs, against Anaplasma infections in cattle and against Ehrlichia canis infections in dogs. The prolonged action of Imidocarb dipropionate exerts a prophylactic effect against Babesia infections for up to 6 weeks.

INDICATIONS:

Imidocarb 120 Inj. is indicated for the treatment and prevention of Babesiosis in cattle, sheep, horses and dogs, for the treatment of Anaplasmosis in cattle and Ehrlichiosis in dogs.

CONTRA-INDICATIONS:

Do not administer to extremely weak animals. Do not use in ewes in lactation if milk is intended for human consumption.

SIDE EFFECTS:

A painful, inflammatory reaction may be seen at the injection site, even during a few days. Increased salivation, nasal discharge and vomiting can be seen shortly after injection. Some dog and sheep breeds can show transient side effects.

INCOMPATIBILITY WITH OTHER DRUGS:

Do not combine with choline-esterase-inhibiting drugs, pesticides or other chemicals.

DOSAGE AND ADMINISTRATION:

For subcutaneous or intramuscular injection.
Treatment:

• Cattle : 1 ml per 100 kg bodyweight. In treating mixed infections due to Anaplasma and Babesia, administer 2.5 ml per 100 kg bodyweight.

• Sheep : 0.5 ml per 50 kg bodyweight.

• Horses : 2 ml per 100 kg bodyweight (intramuscular injection is preferred). In most cases, a single dose will effect a complete cure, but the treatment of B. equi infections in horses may require 2 doses at an interval of 24 hours.

• Dogs : 0.25 ml per 10 kg bodyweight. In treating mixed infections due to Ehrlichia and Babesia, administer 0.5 ml per 10 kg bodyweight, 2 doses at an interval of 14 days.

It is advised to screen the blood after one treatment for presence of the parasite. Repeat treatment if the test is positive.
Prevention:

• Cattle : 2.5 ml per 100 kg bodyweight. A single dose will prevent Babesiosis for up to 4 weeks depending on the severity of the challenge and species involved.

• Horses : 2 ml per 100 kg bodyweight (intramuscular injection is preferred).

• Dogs : 0.5 ml per 10 kg bodyweight. A single dose will prevent Babesiosis for up to 4 weeks.

• Sheep : 1 ml per 50 kg bodyweight.

WITHDRAWAL PERIOD:

Meat : 90 days
Milk : 7 days

STORAGE:

Store in a dry, dark place between 8 °C and 25 °C.
Keep medicine away from children.

PACKING:

50 ml multidose vial, packed in individual box (105 vials per box).



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Vet Rec. 1980 Sep 20;107(12):275-7.

A comparison of the efficacy of imidocarb dipropionate and tetracycline hydrochloride in the treatment of canine ehrlichiosis.

Price JE, Dolan TT.

Abstract

A comparison of the efficacy of imidocarb dipropionate solution and tetracycline hydrochloride in the treatment of naturally occurring ehrlichiosis of dogs presented at the University of Nairobi small animal clinic was carried out. Five to 7 mg per kg imidocarb dipropionate given intramuscularly twice at an interval of 14 days was as effective as 14 daily, oral doses of 66 mg per kg tetracycline hydrochloride in alleviating the clinical signs of disease. Imidocarb eliminated the infection in 81 per cent of the cases whereas tetracyclines cleared only 25 per cent as judged by cell culture isolation. Imidocarb had the further advantage of controlling concurrent babesiosis. The majority of dogs showed some transient side-effects after administration of imidocarb, while a small proportion of dogs dosed with tetracycline reacted adversely and dosage had to be reduced or stopped.


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Imochem-120

Imidocarb 12% injection

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Solution for parenteral administration

• Composition
• Contains per ml:
• Imidocarb dipropionate
  120 mg.
• Excipients ad
  1 ml.

Description

Imidocarb is a diamidine of the carbanalide series of antiprotozoal compounds.

Indications

Imochem-120 is indicated for treatment and prophylaxis of babesiosis in cattle, for treatment of babesiosis and anaplasmosis in sheep, for treatment of babesiosis in horses and dogs and for treatment of anaplasmosis in cattle.

Contra indications

Administration to animals exposed to cholinesterase-inhibiting drugs or pesticides.
Administration via the intravenous route.
Administration to ewes producing milk for human consumption.
Administration to animals with impaired renal and/or hepatic functions.

Side effects

Most common adverse effects include pain during injections and mild cholinergic signs (salivation, vomitting, nasal drip). Cholinergic side effects may be alleviated by treatment with atropine sulphate. Other effects may include panting, diarrhoea, injection site inflammation, lacrimation, sweating and restlessness.

Dosage

Dosage:
For parenteral administration.
Calves and cattle:
Babesiosis
Treatment of babesiosis : 1.0 ml per 100 kg body weight, subcutaneously.
Prevention of babesiosis : 2.5 ml per 100 kg body weight, subcutaneously, one month before
exposure.
Anaplasmosis
Treatment of anaplasmosis : 2.5 ml per 100 kg bodyweight, subcutaneously.
Elimination of the carrier state : 4.0 ml per 100 kg bodyweight, subcutaneously, administered twice with a 14-day interval.
Horses:
Treatment of Babesia caballi : 2.0 ml per 100 kg body weight, once daily for 2 consecutive days, intramuscularly.
Treatment of Babesia equi : 3.5 ml per 100 kg body weight, administered 4 times with a 72-hour interval.
Sheep : 1.0 ml per 100 kg body weight, intramuscularly.
Dogs : 0.5 ml per 10 kg body weight, subcutaneously or intramuscularly. Repeat the dose in 2 weeks, for a total of 2 treatments.