THE SURGICAL PATIENT
ZOLETIL
Zoletil(R) is a combination of a dissociative anesthetic
agent, tiletamine hypochloride, and a tranquilizer, zolazepam
hypochloride.
Zoletil(R) is very comfortable to use thanks to:
In dogs:
- Average dosage: 5-7 mg/kg
- Lethal dosage: 100 mg/kg
In cats:
- Average dosage: 7-10 mg/kg
- Lethal dosage: 220 mg/kg
- No cardiorespiratory depression
- No epileptic effect
- Transient decrease of body temperature
- No hepatic or renal toxicity
- Laryngeal, palpebral, and pharyngeal reflexes are maintained
- Can be used on pregnant bitches and queens
- Fast onset of action: within 1 minute by IV route, 3-5 minutes by IM route
- Good anesthetic effect
- Instantaneous muscle relaxation
- Immediate superficial analgesia
- Smooth awakening: between 30 minutes to 2 hours
Zoletil(R) is a very convenient injectable anesthetic agent:
The following indicative guidelines will illustrate how Zoletil(R) can be used in a variety of procedures in cats and dogs, ranging from restraint to orthopedic surgery.
General advice
FoodIt is advisable to withhold food for 12 hours before injection of Zoletil(R).
Body temperature should be monitored Animals should be protected from body heat loss.
The eyes normally remain open with the pupils dilated. The use of an ophthalmic ointment is advisable to protect the cornea from desiccation.
Do not exceed the maximum safe dose of 72 mg/kg of bodyweight in cats.
Recovery time depends on doses, injection route, general status of the patient.
Smooth recovery in cats.
For an optimum recovery, the patient should be kept away from loud noises and bright lights.
Non-reconstituted product should be used within 2 years. Once reconstituted, Zoletil(R) can be kept 8 days at 4°C (over 90% efficacy maintained).
Factors affecting response to immobilizing medicines include:
- age, sex, reproduction status
- general nutritional status (obesity)
- concomitant diseases
Doses are flexible taking into account the status of the subject.
Doses should be reduced in geriatric and debilitated patients.
Sedation
Zoletil(R) is indicated for minor procedures such as immobilization and handling, diagnostic examination and restraint:
- Allows a good quality sedation
- Onset of action is quick:3-5 minutes
- Zoletil(R) 5 mg/kg
Zoletil(R) is very convenient to use for minor surgeries such as biopsies, wound cleaning, suturing:
- Short duration anesthesia is possible
- Easy to administer by IM route
- Highly safe for the patient
- Does not lower blood pressure
- Premedication: 15 minutes before induction glycopyrrolate (0.01 mg/kg IM or SC) or atropine (0.05 mg/kg SC)
- Induction: Zoletil(R) 5-7 mg/kg IM
- Preserves the laryngeal reflex so there is no need for intubation
- Easy to use
- Allows muscle relaxation, needed because procedures often need a mouth large open
- Premedication: 15 minutes before induction atropine (0.05 mg/kg SC) to reduce salivation
- Induction: : Zoletil(R) 10 mg/kg IM
- Premedication: 15 minutes before induction atropine (0.05 mg/kg SC) to reduce salivation
- Induction: Zoletil(R) 15 mg/kg IM
- Highly safe for this type of patient:
Tiletamine has no direct effect on kidney functions, so it avoids bradycardia and hypovolemia - Allows muscle relaxation and sedation
- A maintenance protocol is possible
Zoletil(R) has no cumulative toxicity so it can be re-injected
- Renal checkup
- Premedication:15 minutes before induction atropine (0.05 mg/kg SC)
- Induction: Zoletil(R) 5 mg/kg IM
- Maintenance: Inhalation anesthesia or Zoletil(R) (2-3 mg/kg IM) if needed
- Fluid therapy necessary during anesthesia and post surgery
- Short duration anesthesia is possible
- Easy to administer by IM route
- Highly safe for the patient
- Premedication: 15 minutes before induction glycopyrrolate (0.01 mg/kg IM or SC) or atropine (0.05 mg/kg SC)
- Induction: Zoletil(R) 7 mg/kg IM
- a short duration one
- with a short lap between induction and delivery
- with a flexible dose regime
- cause only a mild respiratory depression in kittens
- Highly safe for the mother and kittens:
Zolazepam has no depressant effect on the respiratory system,
Tiletamine does not lower arterial pressure - Allows a quick awakening of the mother without hypothermia
- Premedication: 30 minutes before induction glycopyrrolate (0.01 mg/kg IM or SC) doesn't pass through the placental barrier
- Induction: Zoletil(R) 7-10 mg/kg IM
- Perfusion: Ringer lactate (5 mL/kg per hour)
- Place animal in supine position as late as possible (light inclination on the side preferable)
- Mask oxygenation or intubation
- Once newborns are delivered, anesthesia of the mother can be deepen
- Care to newborns:
- If respiratory depression: doxapram + oxygen therapy
- If bradycardia: atropine 0.04 mg/kg IM
- If mother in state of chock: keep placenta for it will provide a blood supplement to newborns
- Easy to administer by IM
- Highly safe anesthetic agent for the patient
- A maintenance protocol is possible, if surgical procedure
is to be extended (e.g. pregnancy or metritis)
Zoletil(R) has no cumulative toxicity so it can be re-injected
- Premedication: 15 minutes before induction glycopyrrolate (0.01 mg/kg IM or SC) or atropine (0.05 mg/kg SC)
- Induction: Zoletil(R) 7-10 mg/kg IM
- Maintenance:Zoletil(R) 2.5 mg/kg IM if needed
- Brings an efficient and safe approach to performing basic bone surgery anesthesia
Zoletil(R) has no cumulative toxicity
Zolazepam is quickly eliminated - An instantaneous muscle relaxation is observed
- Premedication: 15 minutes before induction glycopyrrolate (0.01 mg/kg IM or SC) or atropine (0.05 mg/kg SC)
- Induction: Zoletil(R) 10-15 mg/kg IM
- Maintenance: Zoletil(R) 5-7 mg/kg IM
- Note: As Zoletil(R) shows mild analgesic effects, adequate management of pain should be performed (NSAIDs, opioids)
--------------------------------
Zoletil 50 Rx
G: Per vial w/ powder:
Tiletamine HCl 125 mg, zolazepam base 125 mg. Per solvent vial:
Sterilized water for inj 5 mL, reconstituted soln 50 mg/mL.
A: Zoletil 50 is a general injectable anesthetic agent. Tiletamine is a dissociative anesthetic agent. Zolazepam is a sedative, an anxiolytic and a muscle relaxant. It enhances the tiletamine depression of the CNS. It also prevents seizures due to tiletamine and improves both muscle relaxation and recovery from anesthesia. Zoletil 50 produces a state of unconsciousness that has been referred to as dissociative because it appears to selectively interrupt association pathways to the brain. Depending on the animal species, analgesia persists after the anesthetic effect has subsided. Pharyngeal and laryngeal reflexes remain intact. Cranial nerves and spinal reflexes remain intact. Consequently, the animal’s eyes remain open and the animal can swallow, move its tongue, chew, blink its eyelids and move its limbs during the anesthesia. The actions of Zoletil 50 can be summarized as follows: Catalepsy: Rapid, w/out agitation, followed by muscular relaxation. Analgesia: Immediate superficial analgesia, moderate visceral analgesia. Surgical anesthesia: With muscular relaxation, persistence of laryngeal, pharyngeal and palpebral reflexes, no depression of respiratory center, possibility of salivation.
I: Induction of anesthesia prior to inhalants or as a sole anesthetic agent for a wide variety of diagnosis and short duration surgical procedures of minor severity in cats, dogs and many wild and exotic animals.
D: Premedication – Atropine sulfate: Dogs- 0.1 mg/kg by SC, 15 mins before inj of Zoletil. Cats – 0.05 mg/kg by SC, 15 mins before inj of Zoletil. Induction – Mix extemporaneously the contents of the powder vial w/ the solvent. By IM – Loss of righting reflex in 3-6 mins. By IV – Loss of righting reflex on <1 10-15="" 100="" 10="" 30="" 5="" 7-10="" 7.5="" 72="" additional="" and="" anesthesia:="" be="" both="" bw.="" bw="" by="" can="" cats-="" cats="" cumulative="" dogs-="" dogs="" dosage="" dose="" doses="" ed.="" effect="" examination:="" examination="" exceed="" has="" im="" in="" initial="" injected="" iv="" kg="" lethal="" maximal="" mg="" min.="" minor="" no="" not="" of="" reinject="" safe="" shld="" short="" should="" species="" strong="" surgery:="" surgery="" that="" the="" to="" total="" varies="" w=""> non-domestic animals1>
A: Zoletil 50 is a general injectable anesthetic agent. Tiletamine is a dissociative anesthetic agent. Zolazepam is a sedative, an anxiolytic and a muscle relaxant. It enhances the tiletamine depression of the CNS. It also prevents seizures due to tiletamine and improves both muscle relaxation and recovery from anesthesia. Zoletil 50 produces a state of unconsciousness that has been referred to as dissociative because it appears to selectively interrupt association pathways to the brain. Depending on the animal species, analgesia persists after the anesthetic effect has subsided. Pharyngeal and laryngeal reflexes remain intact. Cranial nerves and spinal reflexes remain intact. Consequently, the animal’s eyes remain open and the animal can swallow, move its tongue, chew, blink its eyelids and move its limbs during the anesthesia. The actions of Zoletil 50 can be summarized as follows: Catalepsy: Rapid, w/out agitation, followed by muscular relaxation. Analgesia: Immediate superficial analgesia, moderate visceral analgesia. Surgical anesthesia: With muscular relaxation, persistence of laryngeal, pharyngeal and palpebral reflexes, no depression of respiratory center, possibility of salivation.
I: Induction of anesthesia prior to inhalants or as a sole anesthetic agent for a wide variety of diagnosis and short duration surgical procedures of minor severity in cats, dogs and many wild and exotic animals.
D: Premedication – Atropine sulfate: Dogs- 0.1 mg/kg by SC, 15 mins before inj of Zoletil. Cats – 0.05 mg/kg by SC, 15 mins before inj of Zoletil. Induction – Mix extemporaneously the contents of the powder vial w/ the solvent. By IM – Loss of righting reflex in 3-6 mins. By IV – Loss of righting reflex on <1 10-15="" 100="" 10="" 30="" 5="" 7-10="" 7.5="" 72="" additional="" and="" anesthesia:="" be="" both="" bw.="" bw="" by="" can="" cats-="" cats="" cumulative="" dogs-="" dogs="" dosage="" dose="" doses="" ed.="" effect="" examination:="" examination="" exceed="" has="" im="" in="" initial="" injected="" iv="" kg="" lethal="" maximal="" mg="" min.="" minor="" no="" not="" of="" reinject="" safe="" shld="" short="" should="" species="" strong="" surgery:="" surgery="" that="" the="" to="" total="" varies="" w=""> non-domestic animals1>
P: Salivation is occasionally observed and can be controlled by administration of anticholinergic drugs, such as atropine, before anesthesia. Reduce dose when other anesthetic agents are used.
Pr: Vial 10 mL + 1 solvent (5 mL) per box.
VR-2831 2012-04-03 125 mg/125 mg
http://www.slideshare.net/kkrimetz/rat-anesthesia
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