388. Antisedan effects after waking up the dog

Injectable anaesthesia in the healthy dog and cat
in one syringe. Calculated dosage for healthy animals
Weight
Domitor
Ketamine
10kg healthy
0.4 ml IV
0.5 ml IV



Domitor 5-40ug/kg = 0.005mg/kg-0.04mg/kg
Ketamine 2-5mg/kg
Heart-diseased dogs - Do not use domitor+ketamine
Old dog - Use less domitor
Injectable anaesthesia in the healthy dog and cat
in one syringe. Calculated dosage for healthy animals
Weight
Diazepam
Ketamine
10kg healthy
0.8 ml* IV
0.5 ml IV



Diazepam 0.1-0.4 mg/kg.
* is based on maximal dose
Ketamine 2-5mg/kg
Heart-diseased dogs - give 50% + isoflurane gas top up
Spay healthy dogs - give higher dose in the higher range. No need isoflurane gas top up.



Rabbit & Guinea Pig. Use Subcutaneous inj only
in one syringe
Weight
Domitor
Ketamine
1kg healthy
0.2 ml SC
0.1 ml SC



Domitor 0.02 -0.25 mg/kg
Ketamine 10 -15mg/kg

DETAILS:
Domitor 1mg/ml = 1,000ug/ml
Ketamine 100mg/ml
Diazepam 5mg/ml

CASE STUDIES OF 3 DOGS USING DOMITOR+KETAMINE
Weight
Domitor
Calculated
Ketamine
Calculated
Domitor Given
Ketamine Given
10kg healthy
0.4 ml IV
0.5 ml IV







Case 1
Fox Terrier, 1 year, 9.3kg spay
0.37 ml IV
0.47 ml IV
0.2 ml IV
0.3 ml IV
Young, healthy
Needs isoflurane maintenance as dosage is below calculated dose. No problems. When antisedan 0.2 ml IM is given, wakes up alert but limbs are rigid. Can't stand up till atropine 0.1 ml IV is given.





Case 2
Shih Tzu, F, 7 years, 8.1 kg
0.32 ml IV
0.41 ml IV
0.1 ml IV
0.4ml IV
Old age, be careful
Needs isoflurane maintenance as dosage is below calculated dose. No problems. Dental scaling. When antisedan 0.1 ml IV is given, no cries. Just wakes up as if from a nap.
Case 3
Maltese, F, 8 years, 4.3 kg
0.17 ml IV
0.22 ml IV
0.1ml IV
0.2ml IV
Old age, be careful
No need isoflurane gas as dosage is close to calculated dose. 6 teeth extracted. No problem. When antisedan 0.1 ml IV is given, cries in pain. Given tolfedine injection. Stops crying.
Dosage for the two old dogs - shih tzu and maltese



Fox Terrier, 1 year, Spayed. Rigid limbs after giving antisedan
to wake up the dog early



In conclusion, domitor and ketamine are synergistic and their combined use will be safer if injectable anaesthetics are required and no isoflurane gas is available. For healthy dogs, use the calculated dosage given above. For heart-diseased dogs, use diazepam + ketamine at 50% of calculated dose and give isoflurane gas top up. Do NOT use domitor + ketamine is heart-diseased dogs.



As google does not permit proper table to be set up or I don't know how to do it, see Toa Payoh Vets webpage at:
http://www.kongyuensing.com/folder5/20110326injectable-anaesthesia-dogs-cats-rabbits-guinea-pigs-toapayohvets.htm
for an easier to read tabulated pres

entation of the 3 cases.