Wednesday, June 25, 2025

4158. FLORA SINGAPORE. The Little Ironweed (Cyanthillium cinereum). How to get...

 

 

 

 

FLORAL SINGAPORE:
PHOTOGRAPHY TIPS:

Cyanthillium cinereum (Little Ironweed) is a shrub in the sunflower family. 

It is difficult to get sharp images of the puffball-like fruits as they are small, less than l0 mm across. Use a tripod. The settings of the photo in the video are as follows: 

1. Canon R5, AV Mode
2. 80mm

3. 1/80 sec
4. f/11
5. ISO 160

6. Tripod gives you sharp images

 

UPDATES:
https://2010vets.blogspot.com/2025/06/4157-photography-tips-little-ironweed.html

4157. PHOTOGRAPHY TIPS: Little Ironweed (Cyanthillium cinereum)

FLORAL SINGAPORE:
PHOTOGRAPHY TIPS:

Cyanthillium cinereum (Little Ironweed) is a shrub in the sunflower family. 

It is difficult to get sharp images of the puffball-like fruits as they are small, less than l0 mm across. Use a tripod. The settings of the photo in the video are as follows: 

1. Canon R5, AV Mode
2. 80mm

3. 1/80 sec
4. f/11
5. ISO 160

6. Tripod gives you sharp images

 

UPDATES:
https://2010vets.blogspot.com/2025/06/4157-photography-tips-little-ironweed.html

 

 



 

Tuesday, June 24, 2025

4156. Prostate cancer. Darolutamide and proteins like AR-V7

 

Darolutamide, marketed as Nubeqa, is a medication used to treat prostate cancer. It's an androgen receptor inhibitor, meaning it blocks the effects of testosterone and other androgens that can fuel cancer growth. It's often used in combination with other treatments like androgen deprivation therapy (ADT) and docetaxel, depending on the stage and characteristics of the cancer. 
Here's a more detailed breakdown:
What it is: Darolutamide is an oral medication that specifically targets androgen receptors, preventing them from receiving signals that promote prostate cancer cell growth. 
How it's used:
  • Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): Darolutamide is used in combination with ADT and docetaxel. A recent FDA approval allows its use in this setting. 
  • Non-metastatic Castration-Resistant Prostate Cancer (nmCRPC): Darolutamide is used with ADT. 
  • Advanced Prostate Cancer: It may be used with other hormone therapies if other treatments have stopped working. 
Why it's used:
  • Extends survival:
    Clinical trials have shown that darolutamide, when combined with other therapies, can significantly increase overall survival in men with mHSPC. 
  • Delays cancer progression:
    It can also delay the progression of prostate cancer, including time to prostate-specific antigen (PSA) progression, in men with nmCRPC. 
  • Improves PSA response:
    Darolutamide can lead to a higher proportion of men achieving undetectable PSA levels. 
  • Good safety profile:
    Darolutamide has been shown to have a favorable safety and tolerability profile, with side effects comparable to placebo in some studies. 
Important Considerations:
  • Consult with a doctor:
    It's crucial to discuss with a healthcare professional to determine if darolutamide is the right treatment option based on individual circumstances. 
  • Combination therapy:
    Darolutamide is often used in combination with other treatments, and the specific combination will depend on the patient's situation. 
  • Potential side effects:
    While darolutamide is generally well-tolerated, potential side effects can include fatigue, diarrhea, and musculoskeletal pain. 
  • Cost and access:
    Darolutamide and other similar drugs can be expensive, and access may be a barrier for some patients. 
     
    -------------------
     
    TIMES ENTERTAINMENT
    https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/proteins-
    that-block-prostate-cancer..........
     
     
      
    Standard treatments sometime fail because certain proteins like AR-V7 
    allow cancer cells to survive and grow even when hormone-blocking drugs
    are used, reducing the treatment's effectiveness.

     Doctors can test for protein activity before beginning hormone therapy. If high levels
    of these proteins are detected, choose alternative treatments or
    advanced therapies rather than standard 
    that may be ineffective.
     
    Scientists are now developing targeted drugs that can block AR-VR and other
    proteins that interfere with treatment, increasing the chance of long-lasting
    treatment success.
     
    By identifying protein activity in advance, doctors can create customised treatment 
    plan for each patient. New targeted drugs offer hope for men living with
    prostate cancer.
     
      

4155. Wild mushroom

 
 
--------------------------
 
 
23 Jun 2025
 
 
 
23 Jun 2025, 5.11pm
Tripod
Manual mode
97mm, 1/30 sec, f/4, ISO 200.  

 


4154. Wildlife Singapore. Yellow-vented Bulbul.

Pycnonotus goiavier ; Common Name: Yellow-vented Bulbul ; Ecological Notes, They are fond of berries and small fruits, especially figs and cinnamon tree fruits.

 The most common urban bulbul in Southeast Asia, this attractive songster is a common sight in cities, parks, and plantations, as well as in open forests, edges, and secondary growth. Brown above and whitish below with a bright yellow vent and a thick black line between the bill and the eye. Front edge of the weak, slightly peaked crest is also dark. Gives rolling, variable song and bubbly multiple-note calls.

SINGAPORE - SEP 2019: 8 am. The Yellow-vented Bulbul (Pycnonotus goiavier) is found in scrubland, parkland and urban areas, except in deep forests. It is seen more often than other bird species. 

 

----------------------------

 

3 JULY 2025

9.45AM   SINGAPORE ZOO

 

Olive-winged Bulbul (Pycnonotus plumosus). 
Brown feathers, yellowish-olve flight feathers and dark red eyes

 



 

Canon R5, 99mm, 1/2000 sec, f/4.5, ISO 400, TV MODE
face threats from the caged-bird and exotic pet trade.

 

 --------------------------------

 








 

 

 

Monday, June 23, 2025

4153. VET CASE STUDIES X 2. A cat with a swollen right face. A cat with ear cancer (Squamous cell carcinoma) & Tissue margins in histology reports

This blog has two Vet Case Studies.

1. A sneezing cat has a swollen right facial swelling.
2. A cat has left ear cancer.

-----------------------------------

 

VET CASE STUDY 1. 

 






 
 





 
 





 
 
 





 
 





 
 
 





 
 
 
 






 
 
 
 

  
 
VIDEO IN YOUTUBE
 
 

 

 

 

 

 

 

 

 

 















































































 

 

 

 

 

 

 

-------------------------------------- 

VET CASE STUDY 2.  

Squamous cell carcinoma (SCC) is a type of skin cancer. It appears in white or light-coloured fur of the cat's ear tips, nose and eyelids.

Caused by chronic exposure to ultraviolet radiation from the sun.

Presented as scabs or sores that progress to ulcerated red and weepy areas.

Recurrence can recur, especially if surgical margins are not clear, making follow-up care essential. 


 
Resection margins free of tumor" means that when a surgeon removes a tumor, the tissue surrounding the tumor (the margins) shows no evidence of cancer cells upon microscopic examination by a pathologist. This is also referred to as a "negative" or "clear" margin. It indicates that all visible cancerous tissue has likely been removed during surgery. 

 

  • Resection Margins:

    These are the edges of the tissue that are removed along with the tumor during surgery. 

  • Pathological Examination:

    The removed tissue is sent to a pathologist, who examines it under a microscope to determine if cancer cells are present at the margins. 

  • Negative Margin (Free of Tumor):

    If no cancer cells are found at the edges of the tissue, the margin is considered negative, or free of tumor. This suggests that the entire tumor has been removed. 

  • Positive Margin (Involved Margin):

    If cancer cells are found at the edges of the tissue, the margin is considered positive or involved. This indicates that some cancer cells may remain in the patient, and further treatment (like additional surgery or radiation) may be needed. 

  • Close Margin:

    A close margin is a situation where cancer cells are found close to the edge of the removed tissue, but not actually touching it. The distance considered "close" can vary, but it is often defined as less than 1-2 mm, according to some medical guidelines. 

  • Importance of Clear Margins:

    Achieving clear resection margins is a key goal in cancer surgery, as it is associated with a lower risk of cancer recurrence. 

  • Variations in Definition:

    While a clear margin is generally defined as the absence of cancer cells at the edge of the removed tissue, the specific distance considered a clear margin can vary depending on the type of cancer and the surgical procedure.

 

UPDATE:

https://2010vets.blogspot.com/2025/06/4153-squamous-cell-carcinoma-in-cat.html


-------------------------- 

Squamous cell carcinoma (SCC) is a type of skin cancer that commonly affects cats, particularly those with white or light-colored fur, and is often linked to sun exposure. In cats, SCC frequently appears on the ear tips, nose, and eyelids, presenting initially as scabs or sores that can progress to ulcerated, red, and weepy areas. If left untreated, it can spread to nearby lymph nodes and other organs. 
Key Points about Squamous Cell Carcinoma in Cats:
  • Cause:
    Primarily caused by chronic exposure to ultraviolet (UV) light, especially UVB radiation, from the sun. 
  • Affected Areas:
    Most commonly found on sparsely haired, non-pigmented areas like the ear tips, nose, and eyelids. 
  • Appearance:
    Begins as small scabs or sores, which can then develop into ulcerated, red, and weepy areas. 
  • Progression:
    SCC is locally invasive, meaning it can spread to surrounding tissue, but it is generally slow to metastasize to distant parts of the body. 
  • Risk Factors:
    White cats, cats with little or no pigment, and cats with sparse hair are at higher risk. 
  • Treatment:
    Surgery is often the preferred treatment for localized tumors, and other options include cryosurgery (freezing), radiation therapy, and in some cases, chemotherapy. 
  • Prevention:
    Protecting cats from excessive sun exposure by using pet-safe sunscreen or keeping them indoors during peak sunlight hours is crucial. 
Ear-Specific Considerations:
  • SCC in cats can affect the ear flap (pinna) and the ear canal. 
  • Ear canal SCC can be particularly problematic, as it can spread to the middle and inner ear, potentially impacting hearing and causing neurological issues. 
  • Symptoms of ear canal SCC may include inflamed, itchy, and painful ears, smelly discharge, head shaking, and ear scratching. 
Importance of Early Detection:
Early detection of SCC is critical for successful treatment. Owners should monitor their cats for any suspicious scabs, sores, or changes in the skin, especially on the ears, nose, and eyelids. If any concerns arise, it's essential to consult with a veterinarian promptly for diagnosis and appropriate treatment. 
 
 
--------------------
 
 

Auricular Squamous Cell Carcinoma in Cats

Cats can be afflicted with several types of skin tumors, even on their ears. One type of tumor that can affect the ears is a squamous cell carcinoma. A squamous cell carcinoma (SCC) can be described as a malignant and particularly invasive tumor that takes hold in the scale like cells of the epithelium – the tissue that covers the body or lines the cavities of the body. These scale-like tissue cells are called the squamous.

Carcinoma is, by definition, an especially malignant and persistent form of cancer, often returning after is has been excised from the body and metastasizing to other organs and locations on the body.

An auricular (relating to the ear) squamous cell carcinoma may be caused by excess sun exposure. It is more common in white cats and in cats that have white ears. This type of tumor starts out as red, crusty looking areas on the tips of the ears. The sores, or ulcers, may seem to come and go and will slowly get bigger with time. There may be ulcers on the face as well. This type of cancer can be treated successfully if it is caught early.

Symptoms and Types

  • Red, crusted sores on the edges of the ears
  • Redness may come and go
  • Bleeding ulcers on the ears
  • Ulcers on the ear that slowly get bigger
  • As sores get larger, ear tips may disappear, ear may become malformed
  • Sometimes, sores on the face

 

Causes

  • Excessive exposure to the sun over a long period

Diagnosis

You will need to provide a thorough history of your cat's health leading up to the onset of symptoms. Be sure to describe any sores that have been apparent on other parts of the body, even if you suspect they were caused by injuries resulting from outdoor activity, or from scratching at the skin.

During the examination, your veterinarian will look carefully for other sores or tumors on your cat's body. The lymph nodes will be carefully felt to determine if they are enlarged, an indication that the body is reacting to an infection or invasion. A sample of lymph fluid may be taken to test for cancerous cells. 

Your veterinarian will order complete blood count and biochemistry profile to make sure your cat's other organs are working normally and to determine whether the white blood cell count is higher than normal; again, an indication that the body is fighting an invasive disease or infection.

A biopsy will be taken of the ulcerated tissue on your cat's ear so that your doctor can diagnose the specific type of growth it is, whether carcinoma or a benign mass of tissue. This is necessary for differentiating the ulcers from any other condition that could be causing the same symptoms. 

X-rays images of your cat's chest and skull will allow your veterinarian to visually inspect the lungs for signs of any abnormalities, especially tumors, and to make sure that the carcinoma has not spread into the bones.

Treatment

Treatment will depend on how many ulcers your cat has on its ears and how large the ulcers are. If there is only one small ulcer, it may be removed by cryosurgery, a freezing technique. If the ulcer is larger, or if there are several ulcers, it/they will be treated with surgery. During surgery, most or all of the upright part (pinna) of your cat's ear will be removed. In some cases, the ear canal may also need to be removed. Most cats recover well from this surgery, even if the ear canal needs to be removed.

If surgery is not a practical option, chemotherapy may be used to kill the cancerous cells. However, chemotherapy is not usually as effective as surgery. In some cases, your veterinarian may recommend a veterinary cancer specialist so that you can determine if there are other viable treatment options.

Living and Management

Once your cat has recovered from surgery, it should be able to lead a normal life. Your cat may look different, but it will adjust to its changed body. You will need to monitor your cat closely to make sure it does not develop new sores on its face or head. Try to limit the amount of time your cat spends out in the sun. If you must let your cat out during the daytime, you will need to apply sunscreen to areas of the body that have a thin hair coat. If your cat tends to spend a lot of time on the window sill, you might place a shade or reflector over the glass to block ultraviolet (UV) rays from reaching your cat

As with any cancer, it is recommended that you take your cat for regular progress check with your veterinarian.

Prevention

Limit the amount of time your cat spends in the sun, especially if it is white cat, or if it has a lighter hair coat. When your cat does go out in the sun, apply sunscreen to its ears and nose.



 ----------------
 
AI Overview
Squamous cell carcinoma (SCC) is a common skin cancer in cats, particularly affecting the ear tips, nose, and eyelids of cats with light-colored skin, especially white cats. It is often linked to sun exposure, and can initially appear as small, scabby, black crusty areas that may progress to red, raised, weepy, and ulcerated lesions. Early detection is crucial for effective treatment, which may involve surgery, cryotherapy, or other options. 
Key Characteristics:
  • Sun Exposure:
    SCC is strongly associated with UV damage from the sun. 
  • Appearance:
    Initially, it may look like a non-healing scab or crusty area on the ear, nose, or eyelid. 
  • Progression:
    If untreated, the lesion can progress to an ulcerated area with potential for secondary bacterial infections. 
  • Location:
    SCC commonly affects the ear tips and ear canal, but can also be found on the nose and eyelids. 
  • White Cats:
    White cats, or those with white patches, are more susceptible due to their lack of protective pigmentation. 
  • Slow to Spread (Generally):
    While SCC is locally invasive, it tends to spread to other parts of the body more slowly than other cancers. 
  • Diagnosis:
    A fine needle aspiration (FNA) or biopsy can help confirm the diagnosis. 
  • Treatment:
    Treatment options include surgery, cryotherapy (freezing), or radiation therapy, depending on the stage and location of the cancer. 
Important Considerations:
  • Early Detection:
    Regular skin checks and prompt veterinary attention for any suspicious lesions are vital for successful treatment. 
  • Sun Protection:
    Limiting sun exposure and using pet-safe sunscreen on vulnerable areas can help prevent SCC. 
  • Multicentric SCC:
    In some cases, SCC can affect multiple locations, and treatment may involve a combination of approaches. 
  • Prognosis:
    While generally slow to spread, SCC can be aggressive if left untreated, potentially affecting the ear canal and deeper structures. 
  • Recurrence:
    SCC can recur, especially if surgical margins are not clear, making follow-up care essential. 
--------------------------------
 
A histopathology report, also known as a biopsy report or surgical pathology report, is a document that details the findings of a pathologist's microscopic examination of tissue samples. These reports are crucial for diagnosing diseases, including cancer, and guiding treatment decisions. 
Key aspects of a histopathology report:
  • Specimen Description:
    The report includes a detailed description of the tissue sample, noting its size, color, and any other macroscopic features. 
  • Microscopic Findings:
    This is the core of the report, where the pathologist describes the tissue's cellular structure, including any abnormalities, such as inflammation, infection, or cancerous changes. 
  • Diagnosis:
    Based on the microscopic findings, the pathologist provides a diagnosis, which may include the type of disease, its stage, and grade. 
  • Prognosis:
    For some conditions, particularly cancer, the report may include a prognosis, which is an assessment of the likely outcome of the disease. 
  • Additional Information:
    The report may also include comments on the tissue margins (the edges of the tissue sample), special stains used, and recommendations for further testing. 
Types of Histopathology Reports:
  • Biopsy Reports: These reports are based on tissue samples obtained during a biopsy, which is a procedure to collect a small piece of tissue for examination.
  • Surgical Resection Reports: These reports cover all the tissue removed during a surgical procedure. 
Importance of Histopathology Reports:
  • Diagnosis:
    Histopathology is a critical tool for diagnosing a wide range of diseases, allowing doctors to accurately identify the underlying cause of a patient's symptoms. 
  • Treatment Planning:
    The information in a histopathology report is essential for developing appropriate treatment plans, including surgery, radiation therapy, chemotherapy, or other therapies. 
  • Prognosis:
    Histopathology helps doctors understand the likely course of a disease and predict the patient's response to treatment. 
  • Monitoring Treatment:
    Histopathology can be used to monitor the effectiveness of treatment and detect any recurrence of the disease. 
Reading a Histopathology Report:
  • Histopathology reports can be complex, so it's best to discuss the report with your doctor or a pathologist.
  • Your doctor can explain the findings in detail, answer your questions, and help you understand the implications of the report. 
  •  -----------------------------------------